Next-generation Molecular Motors: Harnessing Inherently Chiral Carbon Nanostructures

Objective

Biological molecular machines demonstrate how precise control of motion at the nanoscale defines function. Inspired by these natural systems, artificial molecular motors have been developed, yet simultaneously achieving visible-light responsiveness, high photoefficiency, and tunable dynamic properties remains a major challenge. This project proposes an unexplored strategy: integrating overcrowded-alkene molecular motors with inherently chiral helical bilayer nanographenes and π-extended chiral nanohoops. By combining the exceptional optoelectronic and chiroptical properties of these carbon nanostructures with controlled molecular motion, we aim to design next-generation motors—ranging from second to fifth generation—that operate under visible light and no longer require stereogenic carbons for unidirectional rotation. Through systematic synthesis and evaluation, we will investigate new stereoelements based on axial chirality and establish fundamental thermodynamic and kinetic principles governing motor performance. These breakthroughs will enable dynamic modulation of optoelectronic and chiroptical properties, opening pathways for the development of smart functional materials such as responsive membranes, functional surfaces and responsive circularly polarized OLEDs. The project’s high-risk, high-gain approach promises to push the frontiers of molecular motor design and broaden their application scope in nanotechnology and materials science.